Objective
The formation of long-term memory is assumed to depend on the synthesis of new molecules or modifications of pre-existing ones, which contribute to more or less permanent functional changes in synaptic connections, thus shaping preferred pathways as the neural substrate of memory trace. The molecular mecanisms involved in triggering the synthesis of learning and memory related molecules are reported to involve the initial activation of c-fos and c-jun, and numerous data exist about the possible involvement of these two proto-oncogenes in learning and memory. Cell adhesion molecules have also been implicated in learning and memory in different studies, and results obtained support the view that neural adhesion molecules, and in particular N-CAM and L1, may play important roles in stabilisation of memory traces.
The aim of my work could be to determine in different models of transgenic mice, using immunocytochemistry and in situ hybridization, if there is a link between c-fos/c-jun expression and N-CAM/Ll functions and synthesis in learning conditions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20251 HAMBURG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.