Objective
The hypothesis of this project is that adult muscle satellite cells cultured in vitro and implanted into injured myocardium are thought to develop into neomyocardium. Satellite cells will be isolated from adult rat laussimns dorsi muscle and cultured in vitro. To allow confirmation of their presence after implantation into myocardium, an E. coli plasmid pCMVlacZ coding for B-galactosidase and neomycin resistance will be used to label the satellite cells. Transfection will occur by lipofection technique. Prior to implantation, myocardial injury will be inflicted in the same rats which had their muscle explanted by performing a surgical ligature of coronary artery branch. Control, culture medium only, and implant channels will be created into the injured myocardium. The morphology of implanted cells will be analysed microscopically, in addition to functional parameter investigations of whole heart explauts. This technique of cellular eardiomyoplast may present a significant advance in the eure for myocardial infarction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering vehicle engineering aerospace engineering satellite technology
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75671 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.