Objective
I will establish a culture system to isolate and grow the normal precursors of melanocytes ( pigment cells ) from human foetal skin of different ages, by adaptation of a system for murine melanoblasts recently developed in the host laboratory.
I will characterise the markers expressed by the resulting cells by Northern and Western blotting and immunocytochemistry, to determine whether there is one or more than one discrete type of precursor or melanoblast. The effects of individual components and additives in the cultures on the growth and differentiation of these cells will be analysed. These cultures will have many uses related to human pigmentary diseases. A priority will be to examine certain apparently melanoma-specific properties or markers to see whether they are shared with precursor cells. These markers will include the anti-melanoma antibodies of A. Houghton et al., suggested to identify developmentally early and intermediate subsets of melanomas.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW17 ORE London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.