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Regulation of antioxidant and cell cycle genes in response to oxidative stress in plants

Objective



Environmental stresses have been shown to induce strongly and transiently metabolism changes in plant cells such as ion fluxes and a so called oxidative burst. Hydrogen peroxide (H202), the major molecule produced by the oxidative burst was shown to play a dual role in both the induction of antioxidant genes and in the programmed cell death. This
H202-induced-programmed cell death suggests that H2r2 may also involved in down-regulating genes responsible for the cell-cycle progression. Using a synchronisable tobacco cell suspension, the present project aims to answer the following questions: (1) does H202triggers a common signal transduction pathway responsible for the induction of antioxidant genes and the inhibition of cell cycle progression genes ? (2) what are the key steps of this pathway and is it possible to modify them through transgenic approch ? (3) what are the molecular mecanisms involved in the regulation of transcription of the both types of genes ?

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

Universiteit Gent
Address
35,Ledeganckstraat
9000 Gent
Belgium

Participants (1)

Not available
France