Objective
The objective of this research project is to analyse how cells respond to a morphogen gradient. The group of J.B. Gurdon has recently used the Xenopus embryo to create a model system to study the general spatial properties of cellular signaling and response to a morphogen gradient. There is evidence that the artificial concentration gradient of activin they created is achieved by passive diffusion and that cells respond directly to the forming morphogen gradient and can assess morphogen concentration continuously (Gurdon, J.B. et al., Nature 371,487492, 1994; Gurdon, J.B. et al., Nature 376, 520-521, 1995).
In this project, using J.B. Gurdon's assay system for analysing response to a morphogen gradient, we will try to determine: 1) whether activin is required throughout the gradient or whether a non activin signaling molecule is used for distant signal transmission by analysing gene response in distant cells which are dominant negative for the activin receptor. 2) how cell recognize their position in the activin morphogen gradient by analysing the effect of activin receptor overexpression on the spatial arrangement of gene expression 3) how the expression of one gene in the gradient (Xbra) is influenced by that of other early mesodermal genes (Xgscd) by study the effect of overexpression of Xgscd on the spatial arrangement of Xbra expression.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.