Objective
Introduction: The mammalian hippocampal formation is comprised of the hippocampus proper, entorhinal cortex (EC) and subicular complex (subiculum, presubiculum, parasubiculum). The EC and subicular complex process and transmit information between the neocortex and hippocampus. The electrophysiology of EC and subiculum has received little attention, despite their importance in memory formation and involvement in pathophysiological changes associated with dementia and epilepsy. Experimental Outline: The production and regulation of neuronal responses in the subiculum of the mammalian brain will be determined. Recordings will be made from anaesthetized rats. Stimuli will activate the EC and hippocampal CAI inputs to subiculum. Intracellular, extracellular and laminar recording protocols will determine the steady-state responses, neuropharmacology and functional plasticity of these projection systems when activated either singly or in concert. Resultant data will provide important insights into the functions of the subicular complex as the final stage of hippocampal processing and help clarify its role as the interface between the hippocampal formation and the neocortex.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences basic medicine neurology dementia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.