Objective
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder that frequently results in renal failure. The gene for ADPKD1 mapped on chromosome 16pl3.3 has recently been isolated and sequenced. The predicted PKD1 gene product (polycystin) is a protein with multiple domains that indicate that most of the protein is extracellular. The protein is likely to function in cell/cell or cell/matrix interactions. A putative C terminal part of the protein may be involved in signal transduction. The identification of proteins interacting with the polycystin would provide a better understanding of epithelial differentiation and/or its maintenance. We will adress the question of proteins interacting with the putative cytoplasmic tail in signal transdution by using the two-hybrid system. The second aim of this proposal is to distinguish between a dominant negative effect of a mutant Pkdl protein and haploinsufficiency due to inactivation of one allele, as the cause of the disease. This will be done by expression of normal and mutant Pkdl proteins in MDCK cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics chromosomes
- medical and health sciences clinical medicine nephrology kidney diseases
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.