Objective
Cyclins are essential components of the cell cycle regulatory machinery, which act by activating cyclin-dependent kinases. At the beginning of prophase the mitotic kinase, cyclinB1-cdc2, translocates from the cytoplasm to the nucleus. This translocation is probably controlled by phosphorylation in the amino-terminus of cyclin B1 and may be one of the first events in the initiation of mitosis. The aim of this project is to gain better understanding of the initiation of mitosis through: 1) The identification of the mitosis-specific phosphowlation site(s) in cyclin B1.
2) The analysis of the role of phosphorylation in triggering the translocation of cyclin B1 .
3) The purification of the protein kinase responsible for phosphorylation of cyclin B1 at the initiation of mitosis.
An elucidation of the regulation of the cyclin B1-cdc2 complexes is fundamental to our understanding of the controle of mitosis, and is likely to have a bearing on the deregulation of the cell cycle in cancer cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.