Objective
The aim of this research project is to isolate pharmacologically GABA-mediated postsynaptic currents in the nucleus accumbens evoked by stimulation of this structure and to characterise the inhibition of this synaptic input by dopamine. The dopamine receptor involved will be identified. We will study the cellular mechanism involved in the action of dopamine on this current and the presynaptic action of dopamine. I will use and learn whole-cell patch-clamp recordings in brain slices in the laboratory of Dr. M.G. Lacey where this technique is routinely used. This technique is complementary to the ones I already know and is useful to investigate other aspects of dopaminergic transmission in the brain. The experiments suggested in the research project will help us to answer the following questions:
+ Is dopamine depression of inhibitory postsynaptic potentials a direct action on GABA neuron tenninals?
* Is the dopamine receptor involved of the D1 type?
* Does the mechanism involve stimulation of adenylate cyclase?
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.