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Glutamate, vitamin c and molecular oxygen in the mammalian brain - a study using microelectrochemical sensors and microdialysis


The aim of this project is the in vivo characterisation and application of a microelectrochemical glutamate sensor. The sensor, constructed by immobilising the enzyme glutamate oxidase in an electropolymerised poly(o-phenylenediamine) film on the surface of a Pt wire, will be characterised by combining the electrode with a microdialysis probe. This will enable administration of chemicals into the same brain region as the implanted sensor and allow in vivo verification of the signal. Once characterised this sensor will then be used in combination with a carbon paste electrode which simultaneously detects r2 and ascorbic acid (AA) using differential pulse amperometry. The important relationship between glutamate and both M and O2 in the mammalian brain will be investigated. This study will concentrate on the herterexchange theory for M and glutamate, and the relationship between O2, glutamate and neuronal death.
Having being trained in Oxford as an EC Fellow in the in vivo techniques of voltammetry and brain microdialysis (a technique not available in Ireland), this project will enable the candidate to return to his home country to establish and teach the acquired methodologies.

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Stillorgan road belfield
4 Dublin

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