Objective
The aim of this project is the in vivo characterisation and application of a microelectrochemical glutamate sensor. The sensor, constructed by immobilising the enzyme glutamate oxidase in an electropolymerised poly(o-phenylenediamine) film on the surface of a Pt wire, will be characterised by combining the electrode with a microdialysis probe. This will enable administration of chemicals into the same brain region as the implanted sensor and allow in vivo verification of the signal. Once characterised this sensor will then be used in combination with a carbon paste electrode which simultaneously detects r2 and ascorbic acid (AA) using differential pulse amperometry. The important relationship between glutamate and both M and O2 in the mammalian brain will be investigated. This study will concentrate on the herterexchange theory for M and glutamate, and the relationship between O2, glutamate and neuronal death.
Having being trained in Oxford as an EC Fellow in the in vivo techniques of voltammetry and brain microdialysis (a technique not available in Ireland), this project will enable the candidate to return to his home country to establish and teach the acquired methodologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.