Objective
Rheumatoid arthritis is genetically associated with the major histocompatibility complex class II region (HLA-DR4) suggesting involvement of T cell mediated autoimmune recognition of joint specific antigens. Only cartilage contain joint-specific proteins. The most widely used model is arthritis induced with type II collagen (CII), The major protein component of cartilage. To understand the role of CII-reactive T-cells a series of precisely designed transgenic mice are available in Lund. This includes mice with human CII instead of mouse CII in cartilage (obtained by crossing human CII transgenic with mouse CII deleted mice) and mice with functional expression of human DR4. They have already defined the epitope in human CII recognised by murine T cells. This epitope can be recognised in its glycosylated form. Partially tolerised T-cells against this epitope develop in mice expressing the epitope in cartilage and the mice will eventually develop arthritis. I will analyse the precise nature of the tolerance. The methods I will use include T-cell cloning, cytokine analysis and TCR sequencing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences biochemistry biomolecules proteins
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
221 84 LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.