Objective
We plan to analyze the reciprocal interactions existing between cell adhesion and proliferation. These interactions are suggested by phenomena such as the "anchorage dependence" for G1 to S transition in the cell cycle and "contact inhibition", which are commonly dysregulated in cancer cells. We will analyze in vitro models represented by normal, pre-transformed or neoplastic cells, arrested in GO/G1 by starvation and contact inhibition and subsequently stimulated by adhesion to matrix or specifc antibodies or kept in a non adherent state. Transcripts whose levels are selectively controlled by any of the aforementioned conditions will be differentially analyzed using the "Differential Display of RT-PCR products" (DDRT-PCR) approach, and subsequently cloned for complete characterization. The role of functional cyclin/cyclin-dependent kinase(CDK)/ cyclin inhibitor (CKI) complexes in affecting the adhesive phenotype will be explored at the biochemical and functional level, using synchronized cell populations at defined stages in the cell cycle. The long term goal of the project is to identify early mutational events affecting genes whose expression controls the interdependent functions of adhesion and growth reponse, and whose alterations correlate with tumor progression.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20132 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.