Synthetic saccarides to study the immunological properties of type iii group b streptococcus oligosaccharides

Project Information

Grant agreement ID: FMBI961418

Start date

End date

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

UNIVERSITY OF BIRMINGHAM
United Kingdom

Objective

The aim of this project is prepare synthetically the repeating oligosaccharide unit of type III Group B Streptococcus and derivatives thereof. The compounds will be used for structural (NMR spectroscopy) and immunological studies. The research should establish in detail the conformational control of the sialic acid residue on type III group B Streptococcus polysaccharide. Furthermore, the role of sialic acid on the immunological reaction will be further clarified. An ELISA assay to test ante natal sera for the presence of anti-streptococcus B type specific polysaccharide antibodies will be developed. The research may also lead to the development a novel and rational strategy for the design of synthetic carbohydrate-based vaccines.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › physical sciences › optics › spectroscopy › absorption spectroscopy
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITY OF BIRMINGHAM

• EU contribution: No data
• Address: Edgbaston Park Road ; B15 2TT BIRMINGHAM ; United Kingdom
• Total cost: No data