Objective
Research objectives and content
The project involves a general approach to the synthesis of
conformationally restricted mimetics of B- and Y-turns in biologically active peptides and proteins. The approach will be applied to the peptide hormones vasopressin and oxytocin which are used as drugs. Vasopressin is involved in regulation of urine production and blood pressure, whereas oxytocin causes milk ejection and uterine contractions in mammals. The synthetic routes to the mimetics are short and convergent, and allow facile preparation of mimetics with various side chains at all positions in the turn. The synthesis of the key building blocks in enantomerically pure form relies on the Sharpless epoxidation of allylic alcohols. The mimetics can be elongated at their termini by standard methodology for peptide synthesis and therefore allow facile incorporation into biologically active peptides and proteins.
The prepared analogues of vasopressin and oxytocin containing the mimetics will be evaluated for physiological activity, and their conformations will be determined by a combination of spectroscopic and computational techniques.
It is expected that the analogues will display increased stability on oral administration and that information on the biologically active conformation of the hormones will be obtained.
Training content (objective, benefit and expected impact)
I will get a further improvement of my experience in modern organic synthetic chemistry. Furthermore I will acquire detailled knowledge in the fields of modern peptide synthesis and structure determination by spectroscopic and computational techniques.
Links with industry / industrial relevance (22)
The pharmacological properties of the analogues will be evaluated in collaboration with FERRING Pharmaceuticals in Malmo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
901 87 Umeå
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.