Objective
One of the major challenges is to understand the structural behavior and functionality of cell membranes. Its exceptional mechanical properties combine perfectly flexibility and stability. Elasticity could also provide a mechanism for lipid-prote interactions that can lead to a lipid-mediated selective protein aggregation. This process is also of direct importance in the design of novel biomaterials. From the physical point of view, one of the most fascinating phenomena is the shape changes and local instabilities of cell membranes.
Objective:
By performing Monte carlo simulations of coarse-grained models, we'll be able to deal with systems with a large number c molecules. It will allow us the study of phase transitions and demixing processes, such as protein segregation in membrane and how this process is driven by the generation of curvature in the membrane.
Basic contents:
To study of the effect of membrane proteins on the curvature of lipid-bilayers we'll proceed as follows:
1- Develope a coarse-grained model membrane that reproduces experimental behavior. 2-. Study the effect of protein insertion. How does a bilayer membrane change its local curvature at a particular site where single protein is inserted?, how the geometry of the protein is related to the succesful local bending of the membrane?. 3- Study the lipid-mediated protein interaction process in: (a) Flat membranes and (b) Fluctuating surfaces. 4-.Determine whether protein clustering is driven by the development of curvature.
Training content (objective, benefit and expected impact)
The training aspect of this proposal focusses in getting a deeper knowledge in the main scientific area of the applicant and acquire new methods and techniques of analysis for the system described. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences mathematics pure mathematics geometry
- engineering and technology industrial biotechnology biomaterials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52428 Jülich
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.