Objective The Taxol family of molecules has commanded the attention of the most important synthetic organic chemists due to their unusual tetracyclic structure and, more importantly, to their potent anti-cancer properties. In this project it is intented to develop a new synthetic strategy towards this family of compounds, in which two major fragments are coupled at a late stage in the sequence, and Band C-rings are cyclised in a single step via cation-mediated cascade cyclisation. The cyclohexenyl A-ring acts as a spacer group between the oxetane D-ring acetal and the nucleophilic propargylic silane terminator. The termodynamic driving force for the sequential C-C bond formation will be as a result of formation of increasingly stabilised carbocationic species down the cascade. The novelty of this strategy lies in the cyclisation of a precursor containing intact A and D rings to form B and C rings. Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TC01 - Synthesis, New Molecules and Methods Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Address South kensington SW7 2AZ London United Kingdom See on map EU contribution No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Spain EU contribution € 0,00 Address See on map Other funding No data
