Objective
Maedi Visna virus and Mycobacterium paratuberculosis are common sheep pathogens, causing chronic pneumonia and enteritis, respectively. This project will study the interaction of these pathogens in the ovine lung and the influence of coinfection on the pathogenesis of the pulmonary lesions. Samples from MVV cases, paratuberculosis cases and control sheep will be studied using immunohistochemistry (IHC), polymerase chain reaction (PCR) and in situ hybridisation (ISH) for both pathogens. Tissues with dual infection and MVV-alone will be compared by histopathology and the expression of pathogenesis markers including TGF-B, LFA-1 and -3, L-selectin, VLAX, CD44, hsp65, MHC I and II, CDland macrophage markers. The influence of coinfection on virus transcription, cell phenotype and cytokine production will be assessed in vitro in macrophages. This proposal is based on preliminary evidence of dual infection in the sheep lung and could provide an animal model for the known interaction between HIV and Mycobacterium tuberculosis in the human lung.
Training content (objective, benefit and expected impact)
This programme will provide an excellent training in modern molecular pathology techniques within an active pathology Department. The candidate will acquire skills of research management and execution.
Links with industry / industrial relevance (22)
The Department is developing novel diagnostic tests for MVV that may be of industrial interest.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH9 1QH Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.