Objective
Research objectives and content
The aims of this project are the design and synthesis of new non-conventional analgesics. Bradykinin, a peptide of nine aminoacid residues, is the most potent of the endogenous algogenic substances. Thus, antagonist of bradykinin have a great interest in the treatment and prevention of pain. Since peptidic antagonists are expensive and non-active orally, there is a great interest in the development I of non-peptidic antagonists.
The non-peptidic antagonists known until now will be theoretically studied to develop the basic pharmacophore. Then, new derivatives will be design to fullfil that pharmacophore and those derivatives l more interesting will be synthesized and characterized. Subsequently, the analgesic activity will be | evaluated by an experienced group from the Faculty of Medicine of the U. Complutense of Madrid (Spain). In a feed-back process the biological results will be incorporated into the design and synthesis steps to improve the analgesic response.
Training contents (objective, benefit and expected impact)
Training in molecular modeling and drug design will open new perspectives to the applicant (in a future job search). Moreover, training in synthesis and spectroscopy analysis (nmr, uv, etc.) is fundamental for an organic chemist.
Links with industry/industrial relevance (22)
Members of the research group have and have had contracts with different pharmaceutical companies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28071 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.