Characterisation of tissue vascularisation by magnetic resonance imaging. Quantitative aspects of micro-angiography and perfusion mri experiments for functional imaging

Project Information

Grant agreement ID: FMBI961699

Project closed

Start date 1 July 1997

End date 30 June 1999

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost € 0,00

EU contribution No data

Coordinated by

Institut National de la Santé et de la Recherche Médicale
France

Objective

Our objective is to implement magnetic resonance imaging (MRI) techniques providing bio-scientists and physicians new informations on tissue vascularisation and perfusion. Particular emphasis will be put on the quantitative aspects of the measurements and on fast acquisition schemes which enable dynamical studies.
Applications notably include functional MRI, the characterisation of tissue hypoxia and ischemia situations and of tumour growth. These fields interest both the host group and my source laboratory, the first one particularly in the context of brain studies.
Concretely, the intended work will consist in developing, practically implementing and assessing the most appropriate angiography and perfusion techniques for our purpose. Their limits (minimum spatial and temporal resolutions, reliability; quantitative aspects) will be analysed both theoretically and experimentally, as well as will be their dependence on controllable physiological and acquisition parameters. In vivo animal models on high-field imagers will first benefit from the results before to consider clinical studies on human volunteers. Training content (objective, benefit and expected impact)
I have been working for several years as a physicist in a team of biologists and chemists. It would be of uppermost interest for me to train within a group more oriented towards the physical aspects of MRI. By learning new techniques and by working on more diversified and up-to-date systems, my experience will be enlarged. Moreover, the acquired technical skills will strongly benefit my origin laboratory, whose mastery of contrast agents will turn be most valuable when developing MR micro-angiography experiments in the host group (know-how exchange between European laboratories impact).
Links with industry / industrial relevance (22)
The project is relevant to the pharmaceutical industry (contrast agents for MR angiography and perfusion) and to MR systems providers. Both laboratories maintain fruitful cooperation with several concerned companies.

Fields of science

• engineering and technology › medical engineering › diagnostic imaging › magnetic resonance imaging

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TP15 - Instrumentation and Applied Physics

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

Institut National de la Santé et de la Recherche Médicale

• EU contribution: No data
• Address: 38043 Grenoble ; France
• Total cost: No data

Participants (1)

Not available

Belgium

• EU contribution: No data
• Total cost: No data