Objective
The aim of the proposed study is to elucidate the interaction of the 16 amino acid long peptide "penetratin" with model membranes formed by phospholipid bilayers in order to improve the peptide efficacity and for a better comprehension of the organization of the membrane. The study will be done by depositing the bilayer on a solid substrate (i.e. silicon) by using the Langmuir-Blodgett technique (transfer of monolayers from the air/liquid interface to solid surfaces). Various techniques will be employed and primarily the technique of neutron reflection from which information will be gained on how the lipids reorganize around the peptide and let it pass through without water leakage. Selective deuteration will be possible to resolve the organization of the four components of the system, that is the hydrocarbon chains, the hydrophilic heads, the water molecules adjacent to the heads and the peptides themselves. Similar peptides with either hydrophilic or hydrophobic character will be used. A full comprehension of the system will be achieved by using techniques different and complementary to neutron reflection both available at the ILL and at the collaborating institutions such as ellipsometry, fluorescence microscopy, infra-red surface spectroscopy, near-field microscopy, differential calorimetry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences analytical chemistry calorimetry
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
38042 GRENOBLE
France
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