Objective
Two basic steps in the investigation of normal development are the identification of regulatory genes and the characterisation c their expression patterns, the latter being are a prerequisite for functional studies. Expression pattern of related genes in different vertebrate species have proven predictable power for other vertebrate species, including man, where gene expression analyses are not easily feasible. We propose to use Xenopus embryo as a vertebrate model system to systematically study gene expression. Our objectives are
? to carry out a molecular screen by in situ hybridisation in Xenopus embryos. documenting and characterizing the expression c 10 000 embryonal expressed mRNAs
? to tag sequence the corresponding cDNAs to match expression patterns to genes and identify genes wlth a potential function i growth control and differentiation
? to establish a Xenopus embryonic gene expression database and install it on the Internet
Training content (objective, benefit and expected impact)
The completion of this research project will train me in various fields. I will gain a general knowledge about development biology problematics and methods: anatomy, concepts on developmental processes... I count on having a more specific knowledge of the Xenopus model and of gene patterning in embryos. I expect that the analysis of the gene patterns will give new and important clues to understand some processes of normal development, in particular mesoderm regionalisation. The us of a vertebrate model of development is of particular interest due to its validity for human development, normal or pathologic The construction and management of the database will give me the opportunity to interact with bioinformatics scientists, and with researchers engaged in similar projects in other organisms (mouse, zebrafish...).
On the whole, my expected training should give me the possibility thereafter to do developmental biology, and to be able tS investigate the functions of genes during vertebrate embryogenesis, including human. I expect to better control bioinformatric to manage and interpret biological data. Given the exponential accumulation of data this should give me the opportunity thereafter to address biological problems using multidisciplinary approaches where bioinformatics, developmental biology, comparative analysis and genome approach play a role.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences internet
- natural sciences computer and information sciences databases
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.