Objective
To study the cooperativity of Fos and the tumor suppressor genes p53 and Rb in the pathogenesis of osteosarcoma in vivo transgenic mice overexpressing exogenous Fos will be crossed with mice deficient for p53 and mice with an inactivated I gene. The phenotype of the offspring will be characterized and compared to littermates expressing only the Fos transgen
Analysis of the murine transgene. and derived cell lines will include morphology and the expression of AP-1-associated genes as well as skeletal markers. The same investigations will be performed for tissues and cell lines derived from neoplastic and non-neoplastic human bone. The second objective of the research project is to generate transgenic mice overexpressing Fra-l to study the effect of this member of the Fos gene family on bone formation und tumorigenesis. By crossing Fra-l transgenic mice with Fos mutant mice, the issue of genetic rescue of the osteopetrotic phenotype of Fos mutant mice will be addressed. Training content (objective, benefit and expected impact)
The work at the l.M.P. will provide me with an intensive training in the molecular basis of bone diseases, especially of bor tumors. The laboratory training will include standard techniques, but also demanding in vivo methods. The training will enable me to perform independent biomedical research later.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1030 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.