Objective
The aim of this proposal is to study protein interactions specific of p130 phosphorylated forms occuring upon cell cycle exit, in order to ascertain novel mechanisms that integrate growth inhibiting and/or differentiating signals and that may be involved in cell transformation when altered. The research strategy will consist in the use of different p130 mutants, involving specific protein domains and phosphorylation sites, as baits in yeast two-hybrid screening assays. The cDNA libraries to be screened will be obtained from particular conditions of cell cycle exit where preliminary work indicates a primary function of p130. The characterise of p130 mutants, of the cDNA clones obtained, and the study of cellular interaction of individual p130 phosphorylated forms will provide a mean of ascertaining the precise role of p130 during cell cycle exit. The training objective of this proposal is to complement my previous research formation with the leading experience of the host laboratory in some aspects of the cell cycle field, in order to conduct independent research in the future. The expected results will be instrumental in understanding processes of cell cycle exit, and they may have relevant implications defining novel mechanisms of cell transformation. The host laboratory is linked to the european biotechnology company Prolifix Results arising from this proposal will be used for application in drug design a production if suitable (see Description of the Host Institute).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.