Objective
Integrins constitute a family of heterodimeric transmembrane glycoproteins involved in cell-substratum or cell-cell interactions. At least 16 alpha and 8 beta subunits have been identified, that may exhibit alternative splicing. Recently, a new muscle-specific splice variant of the B1 subunit has been identified, B1D. B1D is developmentally up-regulated during differentiation of myoblasts and is the most prominent B1 isoform in muscle tissue. Aim of this project is to specify the role of B1D in myogenesis and in muscular physiology. The main objectives include the study of the function of B1D in skeletal and cardiac muscle formation by gene targeting experiments as well as the assessment of its role in myoblast differentiation using an in vitro model. Insights into cell adhesion and integrin-mediated signal transduction will also be gained. Noteworthy, a novel gene targeting approach based on the Cre-loxP system will be used to generate splice variant specific knock-out mice.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine physiology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1066 CX AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.