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Execution of c-myc programed cell death, study in a cell-free system

Objective



Research objectives and content
Using a new approach to study apoptosis induced by the proto-oncogene c-Myc, we hope to prove that this process is under the control of non nuclear events. Our work should provide evidence that cytokines and the proto-oncogene Bcl-2 protect against these effects by modulating these non nuclear events. Focussed on the involvement of ICE-like proteases and their regulation during c-Myc induced apoptosis, _ll-free studies could provide numerous information concerning a pivotal role for these proteases in the cell death program . This study should precise the sequence of c-Myc induced cell death pathway. Our cell-free study could determine how Bcl-2 family and ICE/CED-3 family members interact.
Training content (objective, benefit and expected impact)
The interaction between c-Myc and Bcl-2 represent a novel type of oncogene cooperation of potential importance both in carcinogenesis and in the evolution of resistance in tumors. The availability of a cell-free system reproducing apoptotic events in vitro is a powerful tool to study biochemical events controlling programmed cell death. Unravelling of the molecular mechanisms involved in c-Myc induced proliferation and cell death pathways is important in the understanding of carninogenesis and in the development of their pharmacological control.
Links with industry / industrial relevance (22)
This project is open to collaboration with Tom Cittenden'group (Apoptosis Tech. Inc., Cambridge, MA, USA)

Call for proposal

Data not available

Coordinator

Imperial Cancer Research Fund
EU contribution
No data
Address
44 Lincoln's Inn Fields
WC2A 3PX London
United Kingdom

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Total cost
No data

Participants (1)