Objective
Research objectives and content
Using a new approach to study apoptosis induced by the proto-oncogene c-Myc, we hope to prove that this process is under the control of non nuclear events. Our work should provide evidence that cytokines and the proto-oncogene Bcl-2 protect against these effects by modulating these non nuclear events. Focussed on the involvement of ICE-like proteases and their regulation during c-Myc induced apoptosis, _ll-free studies could provide numerous information concerning a pivotal role for these proteases in the cell death program . This study should precise the sequence of c-Myc induced cell death pathway. Our cell-free study could determine how Bcl-2 family and ICE/CED-3 family members interact.
Training content (objective, benefit and expected impact)
The interaction between c-Myc and Bcl-2 represent a novel type of oncogene cooperation of potential importance both in carcinogenesis and in the evolution of resistance in tumors. The availability of a cell-free system reproducing apoptotic events in vitro is a powerful tool to study biochemical events controlling programmed cell death. Unravelling of the molecular mechanisms involved in c-Myc induced proliferation and cell death pathways is important in the understanding of carninogenesis and in the development of their pharmacological control.
Links with industry / industrial relevance (22)
This project is open to collaboration with Tom Cittenden'group (Apoptosis Tech. Inc., Cambridge, MA, USA)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.