Objective
Research objectives and content
As mesolimbic dopamine neurons may be involved in the pathophysiology of depression and may be a substrate for the therapeutic actions of antidepressant drugs, the proposed study aims at elucidating the role of dopamine in psychosocial stress-induced behavior and in antidepressant action. A new and valid animal model to study this behavior is the subordinate tree shrew. We will investigate whether chronic psychosocial stress induces alterations in density and affinity of dopamine receptors in the tree shrew brain and whether these changes are correlated with changes in locomotor activity. Furthermore, we will approach the question whether antidepressant treatment affects dopamine receptor properties in tree shrews under chronic psychosocial stress.
Training content (objective, benefit and expected impact)
In general, the applicant will gain experience in stress biology research. More specific, the applicant will be trained in receptor binding techniques, which are important tools in contemporary anatomy and pharmacology. Furthermore, experience will be gained in behavioral studies and skills acquired in biochemical assays like RIA and HPLC. Links with industry / industrial relevance (22)
This study could provide indirect evidence for a role of dopamine receptors in the pathogenesis of depression and therefore lead to new targets for antidepressant treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences psychology behavioural psychology
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37077 GOETTINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.