Objective
Research objectives and content
I Discovery of new chemical families active on biochemical fungicidal targets
> To implement a new methodology that could provide new chemical leads in the area of biochemically active compounds by identifying the pharmacophoresknown fungicides and searching for 3D (three dimensions) analogs :
1- Choosing the organic fungicides (up to 4) we want to study (known mode of action).
2- Designing, synthesising and the biochemical testing of structural parts of the molecule to identify the pharmacophore (20 months). 3- 3D modelling of the pharmacophore.
4- Retrieving analogs of this phammacophore in 3D-databases and the screening of these analogs (3 months for the last two parts). The expected benefits are to get bioactive compounds that present better performances than the known compounds i.e. better biological efficacy, better toxicological and/or environmental profile, lower cost... Although 3D analogy approach exists for the discovery of new drugs and was validated in the pharmaceutical industry (see as examples of recent reports 1. Med. Chem. 1995, 38, 3351 and 3566), this approach is novel in the agrochemical field'.
Training content (objective, benefit and expected impact)
> To participate to an applied research project inside a high-level industrial environment
> To increase my knowledge in organic chemistry and biochemistry by working on various types of chemistry appliec io biochemical efficacy. > To leam basic techniques of 3D molecular modelling on the best cquipment available.
Links with industry /industrial relevance (22) I will be hosted in an Industrial Research Laboratory
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences chemical sciences organic chemistry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69263 Lyon
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.