Objective
Research objectives and content Tuberculosis has re-emerged as a major public health problem, a situation which has been exacerbated by the lack of a wide array of chemotherapeutic agents against its causative agent, Mycobacterium tuberculosis, resulting in the development of drug resistant strains. The cell wall of Mycobacterium spp. is essential for growth and survival in the infected host, and some of the most effective antimycobacterial drugs are known to inhibit the biosynthesis of cell wall components . The cell wall is primarily comprised of mycolylated arabinogalactan linked to peptidoclycan and embedded within this matrix is a dominant soluble polysaccharide termed lipoarabinomannan. Although some structural features of these components have been elucidated, the key elements remain to he determined. We propose a programme of research involving structural and conformational analysis of these cell-wall components. Training content (objective, benefit and expected impact) It is intended that this project will offer the candidate training in modern multinuclear multidimensional NMR methods and in molecular modelling techniques applied to carbohydrates. These techniques are currently at he cutting edge of modern structural biology. Links with industry / industrial relevance (22) This project is of industrial relevance in that the host laboratory has an ongoing collaboration with Glaxo Wellcome (UK) on the cell-wall glycans of Mycobacteria.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine pneumology tuberculosis
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.