Objective
Research objectives and content
This project centers on the study of calcium-dependent release of neurotransmitter at inhibitory synapses in the molecular layer of the rat cerebellum.
The cerebellar slice preparation is advantageous for performing simultaneously Cai imaging in identified neuronal processes and electrophysiological recordings from pre- and post-synaptic neurons. At basket cell-Purkinje cell synapses patch-clamp pipettes may be used to control presynaptic excitability and to introduce into presynaptic terminals substances modulating synaptic function.
Using the above preparation and techniques we propose to study the role of several factors determining cerebellar inhibitory postsynaptic currents, including i) failures of action potential propagation, ii) Ca entry following presynaptic depolarization, and iii) Ca release from intracellular stores.
Training content (objective, benefit and expected impact)
The applicant expects to gain extensive experience in combining electrophysiological recordings from pairs of neurons and simultaneous monitoring of intracellular calcium levels with fluorescence imaging methods. The host laboratory has gained a large experience in these techniques in past years, and intends to develop them further during the planned research period. Learning these techniques should endow the applicant with the capability to reach a high technical standard in her own future research projects after returning to Italy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37077 Göttingen - Nikolausberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.