Objective
Research objectives and content
The aim of this project is the further development of photoactivatable Pt(IV)-prodrugs for the treatment of cancer. To achieve this, it is critical that the pathways and reactive intermediates of the photoreactions and the structures of the final photolysis products be known in detail. For these investigations, (1H, 15N) NMR HSQC methods will be employed to study the photochemistry of photosensitive Pt(IV)-complexes. By using 5N-labeled Pt(IV)-complexes, the identity of the primary photolysis products in the presence and absence of single-and double-stranded GG oligonucleotides will be investigated. This will clarify the role of the nucleotide bases in the photochemical reactions. An important goal of this project will be to determine whether the DNA-platinum adducts resulting from the photolysis products are structurally similar to those caused by the clinical-used platinum-based chemotherapeutic agent, cisplatin. Another objective of this project will be to investigate by means of NMR the mechanism of reaction of selected Pt(IV)-complexes with other biomolecules such as glutathione and proteins (e.g. albumin), and to determine the effects of light on these reactions. Whether photoactivated Pt-species induce protein-DNA cross-linking reactions will also be investigated.
A knowledge of the details concerning the photochemistry of
Pt(IV)-complexes will allow us to improve the design of light-activatable Pt(IV)-prodrugs, which could lead to more effective, less toxic therapies of cancer.
Training content (objective, benefit and expected impact)
This postdoctoral fellowship will allow me to learn and practice state-of-the-art NMR techniques in one of the world's most renowned NMR groups. I will also benefit from the expert knowledge of Pro? Sadler in the field of metal-based drugs. The project will give me the chance to investigate in considerably more depth questions that have arisen from my dissertation thesis. In addition, this project will open up new links between the group in Regensburg and the group of Prof. Sadler in Edinburgh.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry organic reactions
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences physical chemistry photochemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH 3JJ EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.