Objective
Research objectives and content The tumor metastasis gene Tiaml was identified through retroviral mutagenesis of T-lymphoma cells followed by screening for invasive phenotypes. This gene encodes a guanine nucleotide exchange factor for the Rho-family small GTPase Rac demonstrating a role for the Rho-family in tumor invasion and metastasis. The normal, non-oncogenic cellular context of Tiaml signalling through Rac has yet to be defined, although Tiaml expression in specific regions of the brain suggests roles in neuronal migration and maturation. Since preliminary data suggests that interacting proteins regulate Tiaml activity we will characterize partners for Tiaml through protein interaction assays. At the same time we will develop transgenic models to elucidate the role of Tiaml in brain tissue development through conditional expression of wildtype, constitutively active and dominant negative Tiaml mutants. This project will improve our understanding of Tiaml function in development and in cancer metastasis. It will demonstrate the utility of emerging techniques applied to investigate this important family of oncogenes. Training content (objective, benefit and expected impact) The training will familiarize me with contemporary techniques in cell biology and give me specialized knowledge in development of transgenic mice and their subsequent analysis. These are techniques which will complement my present expertise in molecular biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.