Objective
Research objectives and content
Hemoglobin is one of the most important proteins in the vertebrate organisms playing the fundamental rtle of oxygen carrier. A better knowledge of its structural characteristics at the atomic level for the oxygen binding is essential for the synthesise of artificial blood, on of the central goal of pharmaceutical industry. This research project aims at the full characterisation through theoretical methods of the binding mechanism. The novelty of this project with respect to previous studies will come from the application of novel theoretical hybrid methods that had not been considered before (IMMON) to state of-the-act molecular dynamics calculations. IMMOM, though its combination of quantum mechanics and molecular mechanics ought to improve substancially our knowledge of the rtle played by the oxygen bindingenvironment. This approach will hopefully provide the first accurate description of the atomic movements involved in the fination of each of the four oxygen molecules bound by each protein sub-unit.
Training content (objective, benefit and expected impact)
This project will offer me the possibility of learning the major theoretical methods and a new one used in chemistry and biochemistry, and to apply them to systems never studied at the atomic level in the bioinorganic.
Links with industry / industrial relevance (22)
The results of these studies should have an important impact on pharmaceutical industry.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08193 BELLATERRA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.