Objective
Research objectives and content
GABAergic interneurones show a large variability in the repertoire of receptors present on their cell surface. Furthermore networks of GABAergic interneurons generate synchronized '40 Hz oscillation' modulating the populations of the principal excitatory cells, a phenomenon underlying the mechanism by which the cortex can associate different features of an object a unified perception. The aim of this research project is the generation of transgenic mice in which one of the GABAA receptors or metabotropic glutamate receptors is selectively knocked out in a specific neuronal population, the GABAergic interneurones, to evaluate if the synchronized "40 Hz oscillation" and the cognitive mechanisms are consequently altered. This result will be achieved using innovative techniques that implies the generation of multiple transgenic mice lines, that can be further used for generating different genetically modified mice lines.
Training content (objective, benefit and expected impact)
This training period will allow me to learn advanced molecular biology techniques, such as generation of transgenic and knock-out mice, and will complete my scientific experience on the cognitive mechanisms field adding a new focus on the role of the GABAergic neurons.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.