New tools for controlling human nk cells functions and cd40-cd40l interaction in nk-tumor cell recognition

Project Information

Grant agreement ID: FMBI972110

Project closed

Start date 16 February 1998

End date 15 February 2000

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

KAROLINSKA INSTITUTE
Sweden

Objective

Research objectives ant content
Our recent finding indicate that CD40-CD40L represent an important NK cytotoxicity activation pathway. One of the objectives of this proposal is to investigate the possibility that CD40 can be expressed on tumor cells and whether it can be recognized by autologous NK cells. The second objective is to generate new monoclonal antibodies panel to NK cells (NKmAbs) able to tune NK cell programs not only related to cytotoxicity function but also cytokine production.
Training content (objective. benefit and expected impact)
The benefit for the proponent is to improve capability to develop new monoclonal antibodies, and strenghted his knowledge in tumor immunology. The expected impact is to make available, a complete reagent panel able to give selective tuning of NK function, moreover the importance of the CD40-CD40L activatory pathway will be determined in a tumor cell system. Links with industry / industrial relevance (22)
The project will be carried out in collaboration with the MABTECH AB (Stockholm), the specific NK mAbs can be patented.

Fields of science

• medical and health sciences › basic medicine › immunology

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TL07 - Immunology and Cancer

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

KAROLINSKA INSTITUTE

• EU contribution: No data
• Address: 13,Nobels väg 16 ; 171 77 Stockholm ; Sweden
• Total cost: No data

Participants (1)

Not available

Italy

• EU contribution: No data
• Total cost: No data