Objective
Research objectives and content
Tryptophan is a fluorescent aminoacid used as an internal probe to get structural and dynamical information about proteins. When embedded in an enzymatic structure, the presence of other aminoacids creates an environment which annihilates the fluorescence. The aim of this project is to develop a molecular model to improve our understanding of these effects and the elucidation of protein structure through tryptophan fluorescence studies. The photophysics of tryptophan and its analogue indole will be studied computationally to assess the physical processes which control the fluorescence quenching by radiationless decay (conical intersections), including the influence of the polarity and acidity of the medium as well as molecular quenching by energy transfer. Highly advanced computational methods (CASSCF, MMVB) partly developed at the KCL Quantum Chemistry Group will be used.
Training content (objective, benefit and expected impact)
This project will allow me to learn the use and practical application of highly advanced computational methods working with Prof. Robb, who has participated in the development and improvement of computational chemistry programs.
Links with industry / industrial relevance (22)
Enzymes are applied in industry as catalysts in synthetic chemistry and in protein engineering, and as biologically active components of washing powders. The results of this project will improve the protein structure elucidation and provide new possibilities for these applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences physical chemistry quantum chemistry
- natural sciences computer and information sciences computational science
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.