Objective
Research objectives and content
We plan to elucidate the thermodynamics of energy transduction of an actin filament moving on a myosin sheet using a light scattering technique. A small-angle scattering geometry, together with a reference phase provided by a phase grating, should allow, according to preliminary calculations, to detect displacements in the 10 nm range. Direct informations on the actin dynamics will be provided by the autocorrelation function of the scattered light. This new non-perturbing technique should lead to data of major interest in the modelling of energy transduction of molecular motors and to study the transition from single to collective behaviours of actin as the density of actin heads is increased.
Training content (objective, benefit and expected impact)
The Institut Curie provides an excellent and well equipped environment with expertises in physics and biology. The expertise in light scattering and noise measurements of the candidate, together with the sample preparation skills at Institut Curie should allow to get significant advance in understanding the thermodynamics of molecular motors. A useful exchange of techniques and skills in complementary fields is expected. Links with industry / industrial relevance (22)
The host institution has several joint programs with industrial partners as Rhone-Poulenc, Elf-Aquitaine and Michelin on the reproduction of the function of molecular motors at mesoscopic scales.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences thermodynamics
- natural sciences physical sciences condensed matter physics soft matter physics
- natural sciences mathematics pure mathematics geometry
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75248 PARIS
France
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