Objective
Research objectives and content
Rhabdoid tumors (MRT) are highly malignant tumors occuring in young children. They can occur in renal or extra-renal localization and are frequently difficult to diagnose. Cytogenetics and molecular biology have indicated that MRT recurrently demonstrate deletion of the proximal part of chromosome 22. This strongly suggests that oncogenesis of these tumors is linked to the inactivation of a presently unknown tumor suppressor gene localized on chromosome 22. This project is aimed at the precise characterization of an MRT cell line, established in the laboratory, which demonstrates an homozygous deletion of chromosome 22. This, together with the analysis of additional MRT will be the basis for a positional cloning approach of the MRT tumor suppressor gene, including construction of cosmid contigs, search for transcription unit and screen for point mutations. Isolation of this new gene would enable to test its alteration in other tumor types characterized by alteration of chromosome 22 and should be important for the development of new diagnostic strategies for MRT. Training content (objective,benefit and expected impact)
- Theoretical and practical training in oncogenesis - Positional cloning strategies - Analysis of gene alteration - Human cancer, pediatric tumors - Interaction between basic science and clinics
Links with industry/industrial relevance(22)
Development of diagnostic tools for small round cell tumors including Ewing tumor, neuroblastoma and MRT
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.