Objective
Research objectives and content
The Epidermal growth factor receptor (EGF-R) is a prototype tyrosine kinase receptor widely expressed in mammalian epitelial tissues, and it has been found to be overexpressed in many tumours of epitelial origin, being a potential target for antitumour therapy. In spite of its functional importance, the three-dimensional structure of the EGF-R is presently unknown. Its determination is of both theoretical and practical interest, since it could lead to the development of new drugs targeting the receptor. The main objective of this project is to obtain the 3D structures of EGF-R and its complexes with EGF and Tgf-alpha by crystallography. The deglycosylated external region will be crystallized alone and in complex with EGF and TGF-alpha. The X-ray diffraction pattern of the crystals will be obtained and analyzed in order to determine the 3D structure of the external region and the complexes. Our approach is innovative in three important aspects It aims to obtain a homogeneous EGF-R external region by using a recombinant deglycosylated polypeptide; it considers the possibility of crystallyzing each domain separately and it constitutes the first attempt to crystallize the EGF-R together with TGF-alpha. This will allow us to determine the ligandreceptor interactions, opening the way to the design of EGF antagonists.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1GA CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.