Objective
Research objectives and content
Eukaryotic cells have evolved a spectrum of mechanisms to cope with DNA damage. A large number of genes encoding proteins involved in the major cellular repair pathway, nucleotide excision repair (NER), have been identified and analyzed. A protein complex, RNA polymerase II transcription factor IIH (TFIIH), has been shown to be involved directly in transcription, DNA repair, and cellcycle regulation. Thus, TFIIH likely represents a main component in the communication of signals from damaged DNA to the transcription and cell-cycle machineries. Therefore, studies of TFIIH function in these processes, and as a molecular switch between them, are crucial for our understanding of the mechanisms cells employ to avoid deleterious DNA damage leading to oncogenic transformation. By combining the power of yeast genetics with molecular techniques and biochemical analyses, I wish to focus my post doctoral training on: Reconstitution of the TFIIH complex from single (recombinant) subunits to define the functional core, and thereby shed light on the specific role(s) of each protein in the complex. And furthermore, characterization of the nucleotide excision repairosome assembly pathway and the conversion of TFIIH from a transcription factor to a repair complex.
Training content (objective, benefit and expected impact)
See above.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EN6 3LD POTTERS BAR
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.