Objective
Research objectives and content
The cellular events which regulate melatonin synthesis in the pineal gland are not well understood. N-acetyltransferase (NAT) is the enzyme responsible for the synthesis of melatonin, and is under the control of a circadian pacemaker in the pineal gland of many vertebrates. The pineal gland of the Zebra fish contains an endogenous circadian pacemaker. I propose to study the circadian transcriptional regulation of NAT activation; which transcription factors and kinases are responsible for the nocturnal increase in NAT transcription. Also the development of the circadian system in the Zebra fish embryo will be examined, as well as the embryonic target tissues of this hormone.
Training content (objective, benefit and expected impact)
As part of this project I wil receive training in a range of molecular techniques available in the laboratory of Dr Sassone Corsi. In addition developmental techniques and the use of the Zebra fish as a model system will be learned. This basic research will have considerable impact on our understanding of melatonin synthesis and function: important information considering the current siqnificance and use of this hormone.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67404 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.