Objective Research objectives and content The main aim of this project is the study of a-amino acid synthesis using new N-dialkylated diketopiperazine based auxiliaries. In order to investigate the regio- and diastereoselective properties of these auxiliaries we shall initiate a programme of research into six areas: 1) An investigation into the general applicability of a novel deprotonation/reprotonation strategy for the preparation of a wide range of a-amino acids. 2) Determination of what protecting groups can be employed for protection on the amidic nitrogens. 3) Development of a new methodology for the preparation of either enantiomer stereospecifically isotopically labelled a-amino acids. 4) Preparation of a wide range of homochiral a,a-bis-alkylated a-amino acids. 5) We wish to implement investigations into a duplication of chirality protocol in order to replicate a-amino acids. 6) Exploration of the possibility of asymmetric synthesis of A,B substituted amino acids by a novel Michael addition approach. Training conent (objective, benefit and expected impact) I think that I shall be able to acquire new knowledges about other methods of asymmetric synthesis of a wide range of homochiral a-amino acids based on stoichometric chiral auxiliaries which are applicable to large scale synthesis. Fields of science natural scienceschemical sciencesorganic chemistryamines Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TC01 - Synthesis, New Molecules and Methods Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Address South parks road OX1 3QY Oxford United Kingdom See on map EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Spain EU contribution € 0,00 Address See on map
