Objective
Research objectives and content
Objective: The migration of ions through membranes in biological cells is of prime importance in life processes, and yet information regarding the various mechanisms involved has been deduced without a knowledge of the structure and dynamics of the ionophores and ion channels, embedded within the membranes. In recent years several surface analytical tools have emerged with the assistance of which one may obtain structural information concerning the arrangement of molecules on various interfaces. Such methods have been applied for probing the structure of Langmuir monolayers and phase transitions of these architectures at the air-liquid interface (via grazing incidence synchrotron X-ray diffraction, X-ray reflectivity, reflectance infra-red spectroscopy) and after transfer to solid support (via local probe techniques, transmission electron microscopy, etc.). In this project we plan to design and analyze model systems of membranes at interfaces and probe the structure, and hopefully ion transport properties, of ion channel molecules and ionophores incorporated within these artificial "membranes". The ion transport molecule we shall focus on valinomycin, a naturally occurring ionophore, as well as synthetic ion-channel molecules such as the cyclic peptides prepared by Ghadiri et al (1,2)
Training content: The training at the Weizmann institute will enable L. Nedelmann to work independently on molecular architecture at surfaces and interfaces. For this purpose, he will learn various experimental techniques (Languir-Blodgett processes, GID) and be provided with the relevant (bio)chemical and crystallographical background.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
76100 REHOVOT
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.