Extent of natural variations and genomic plasticity triggered by iselements and group ii introns in S. Meliloti native populations.

Project Information

Grant agreement ID: FMBI972444

Project closed

Start date 1 September 1998

End date 31 August 1999

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Objective

Research objectives and content
The introduction in the environment of genetic manipulated microorganisms (GMOs) would benefit from studies that demonstrate the extent of natural genotype variations that in turn could result in changes on behaviour.The intrinsic ability of IS elements and Group II Introns for mobility and generation of genetic rearrangements open the possibility that they could cause genetic alterations in GMOs by vertical or horizontal gene transfer. In this project we propose to analyze the extent of natural variations and genomic plasticity triggered by IS elements and Group II Introns in S. meliloti native populations. WP1. Natural variations determined by mobile elements: IS and Group 11 Intron, in S. meliloti GR4-type native populations will be estimated. In addition, the influence if any of agricultural practice in the selection of these variations will be evaluated. WP2. By determining the target sequences of ISRm2011-2 and ISRm2011-2::Rmlntl, the most successful within S. meliloti native populations, we should be able to evaluate the risk that introduction of GMOs based on S. meliloti could be derived from such mobile elements. WP3. The dynamic of IS elements and Group II Intron under
possible stress situations will be evaluated.
Training content (objective, benefit and expected impact)
The candidate should obtain a good expertise and experience on Biosafety. The primary impact of this project is anticipated to be on the scientific community and public audience, providing knowledge and information of fundamental importance in microbial genetics and ecology. On the other hand, the results obtained will help to official authorities in the E.U. in their guidelines and regulations covering the release of GMOs for agricultural purposes or biorremediation. In addition, this project will contribute to determine the amount of natural fluctuation and the extent of natural variation that in turn could be useful for the control and exploitation of safer biotechnological products.
Links with industry / industrial relevance (22)
The results derived from this proposal are envisaged to be of interest for the industry related with the design of biotechnological products based on microorganisms.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › biological sciences › genetics
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › ecology
• natural sciences › biological sciences › microbiology

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Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0303 - Return grants
• TL15 - Population Sciences (inc.Ecology, Evolutionary Sc., Biodiversity & Conserva.)

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• EU contribution: No data
• Address: 1,Profesor Albareda 1 ; 18008 GRANADA ; Spain
• Total cost: No data

Participants (1)

Not available

Spain

• EU contribution: No data
• Total cost: No data