Objective
Research objectives and content
The introduction in the environment of genetic manipulated microorganisms (GMOs) would benefit from studies that demonstrate the extent of natural genotype variations that in turn could result in changes on behaviour.The intrinsic ability of IS elements and Group II Introns for mobility and generation of genetic rearrangements open the possibility that they could cause genetic alterations in GMOs by vertical or horizontal gene transfer. In this project we propose to analyze the extent of natural variations and genomic plasticity triggered by IS elements and Group II Introns in S. meliloti native populations. WP1. Natural variations determined by mobile elements: IS and Group 11 Intron, in S. meliloti GR4-type native populations will be estimated. In addition, the influence if any of agricultural practice in the selection of these variations will be evaluated. WP2. By determining the target sequences of ISRm2011-2 and ISRm2011-2::Rmlntl, the most successful within S. meliloti native populations, we should be able to evaluate the risk that introduction of GMOs based on S. meliloti could be derived from such mobile elements. WP3. The dynamic of IS elements and Group II Intron under
possible stress situations will be evaluated.
Training content (objective, benefit and expected impact)
The candidate should obtain a good expertise and experience on Biosafety. The primary impact of this project is anticipated to be on the scientific community and public audience, providing knowledge and information of fundamental importance in microbial genetics and ecology. On the other hand, the results obtained will help to official authorities in the E.U. in their guidelines and regulations covering the release of GMOs for agricultural purposes or biorremediation. In addition, this project will contribute to determine the amount of natural fluctuation and the extent of natural variation that in turn could be useful for the control and exploitation of safer biotechnological products.
Links with industry / industrial relevance (22)
The results derived from this proposal are envisaged to be of interest for the industry related with the design of biotechnological products based on microorganisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences ecology
- natural sciences biological sciences microbiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
18008 GRANADA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.