Objective
Research objectives and content
A new category of antihypertensive drugs is non-peptide receptor antagonists of the major vasoconstrictor hormone Angiotensin II. It is known that Angiotensin II interacts with lipid bilayers and biological membranes. However, the interaction of its receptor antagonists with membranes hasn't been studied. The subject of the proposed project is the study of the interactions of two receptor antagonists of Angiotensin II with different biological activity with phospholipid membranes. The aim is to investigate if these antagonists exerts different effects on phospholipid bilayers in order to correlate their biological activity with their interaction with membranes. 1 his study requires the combination of valuable and complementary biophysical methods such as spin label ESR spectroscopy, NMR spectroscopy and high resolution differential scanning calorimetry (DSC). The results will contribute to the understanding of the mechanism of action of Angiotensin II receptor antagonists. In this way they could promote the synthesis of new antihypertansive drugs.
Training content (objective, benefit and expected impact)
The execution of the project will allow me to extend my expertise acquired during my Ph.D in the research area of biological membranes. Moreover, in addition to 31p NMR and DSC which I used extensively during my Ph.D I will receive training in ESR spectroscopy, a powerfull technique for studies of biological membranes. Furthermore, the execution of the project provides the opportunity to initiate a collaboration between my laboratory in Greece which work in the field of biological membranes with Max Planck Institute for Biophysical Chemistrv in Goettingen which has long experience at the same scientific area.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences chemical sciences analytical chemistry calorimetry
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37077 Göttingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.