Objective
Research objectives and content
The studies of transcriptional activation in response to interferons have uncovered a novel signal transduction pathway from cell surface receptors to the nucleus. The intracellular signalling events are mediated by two novel families of effectors: the JAK family of tyrosine kinases and the STAT family of transcription factors. The JAK/ STAT pathway was found to be activated by a wide range of cytokines and growth factors. The ubiquitous participation of JAKs and STATs in cytokine and growth factor signalling strongly implies that variants of the proteins and differences in their celluar production levels are associated with diseases or with improved disease resistance. Genomic and cDNA clones of various JAK and STAT proteins of farm animal species (swine, cattle, sheep, rabbit) will be cloned and automatically sequenced. The JAK and STAT clones of farm animal species will be functionally assayed with respect to their ability to genetically complement human cell lines defective in the JAK or STAT proteins. The sequence information obtained will be used to screen these species for polymorphisms in the coding region of the genes as well as in the 5` and 3` regulatory sequences and to isolate JAK/ STAT variants. This will give insight in the evolutionary conservation of these proteins and will help to identify domains wich are important for structure/ function. In addition the data will used to assess the potential impact of JAK/ STAT variants on health traits of farm animals.
Training content (objective, benefit and expected impact)
The training content will include basic molecular genetic techniques. In addition I will gain experience in the handling and and programming of an automated laboratory workstation and of various automated sequencing techniques (single and multicolor gelelectrophoretic sequencing, capillary sequencing.
Links with industry / industrial relevance (22)
None
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3430 Tulln
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.