Objective
Research objectives and content
Recent studies have led to the identification of a new set of proteins (called coactivators) that interact with the nuclear receptors in a ligand-dependent manner playing essential roles in mediating their transcriptional activities. Two of these proteins are SRC-1 (and related proteins) and p300/CBP family. Despite the growing information about these coactivators little is known about how they influence the transcriptional activity. We aim to elucidate the role of SRC-1 and p300/CBP protein families in the transcriptional regulation carried out by nuclear receptors. To do this we propose to: a) Produce SRC-1 and p300/CBP mutants and assay in vivo their abilities to modulate nuclear receptor activity, b) Introduce in intact cells the peptides responsible for the protein interactions testing how they affect the nuclear receptor transcriptional activity.
Training content (objective, benefit and expected impact)
The completion of this proposal would help to define how ultimately nuclear receptors activate transcription and how these activities are regulated by their ligands, offering new insights into molecular controls of many process in which are involved the nuclear receptor superfamily. In addition many of these receptors and their ligands are associated with known human diseases and our results could have a potential impact in posterior trials looking for therapies for these diseases.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.