Objective
Research objectives and content
The application's goal is the identification of molecular mechanisms that are responsible for pancreatic islet infiltration and Beta-cell destruction in insulin-dependent diabetes mellitus (IDDM). The project is divided into two parts: 1.) Determination whether an antigen-specific contact between T-cells and Beta-cells is required for Beta-cell destruction. Using transgenic mice that express a transgenic T-cell receptor specific for influenza hemagglutinin (TCR-HA) and HA in alfa-islet cells under the control of the glucagon promoter (GLU-HA), it will be analyzed if TCR-HAxGLU-HA mice develop diabetes like TCR-HAxINS-HA mice that express HA under the control of the insulin promoter. 2.) Identification of potential mediators of infiltration and Beta-cell destruction analyzing the transcription of candidate genes (chemokines, cytokines and others) in islets that undergo either infiltration or Beta-cell destruction. By studying different animal models of IDDM it will be tested if the findings are generalizable.
For the first time it will be possible to distinguish clearly if Beta-cell death is an antigen-dependent or independent process and which factors are responsible for pancreatic infiltration as well as which are responsible for Beta-cell destruction. Based on these findings new diagnostic and therapeutic strategies can be developed for monitoring and treatment of IDDM already at an early, possibly reversible stage.
Training content (objective, benefit and expected impact)
Learning of new methods and work with another autoimmune model. Finally, the training will provide the basis for a scientific career in Europe. Links with industry / industrial relevance (22)
Temporary consulting agreement with Mirieux, France.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75730 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.