Molecular and cellular mediators of cell death in insulin dependent diabetes mellitus

Project Information

Grant agreement ID: FMBI972604

Project closed

Start date 1 January 1998

End date 31 December 1999

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Objective

Research objectives and content
The application's goal is the identification of molecular mechanisms that are responsible for pancreatic islet infiltration and Beta-cell destruction in insulin-dependent diabetes mellitus (IDDM). The project is divided into two parts: 1.) Determination whether an antigen-specific contact between T-cells and Beta-cells is required for Beta-cell destruction. Using transgenic mice that express a transgenic T-cell receptor specific for influenza hemagglutinin (TCR-HA) and HA in alfa-islet cells under the control of the glucagon promoter (GLU-HA), it will be analyzed if TCR-HAxGLU-HA mice develop diabetes like TCR-HAxINS-HA mice that express HA under the control of the insulin promoter. 2.) Identification of potential mediators of infiltration and Beta-cell destruction analyzing the transcription of candidate genes (chemokines, cytokines and others) in islets that undergo either infiltration or Beta-cell destruction. By studying different animal models of IDDM it will be tested if the findings are generalizable.
For the first time it will be possible to distinguish clearly if Beta-cell death is an antigen-dependent or independent process and which factors are responsible for pancreatic infiltration as well as which are responsible for Beta-cell destruction. Based on these findings new diagnostic and therapeutic strategies can be developed for monitoring and treatment of IDDM already at an early, possibly reversible stage.
Training content (objective, benefit and expected impact)
Learning of new methods and work with another autoimmune model. Finally, the training will provide the basis for a scientific career in Europe. Links with industry / industrial relevance (22)
Temporary consulting agreement with Mirieux, France.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › health sciences › infectious diseases › RNA viruses › influenza

You need to log in or register to use this function

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TL07 - Immunology and Cancer

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

• EU contribution: No data
• Address: 156,Rue de Vaugirard 156 - Hop. Necker-Enfants Malades ; 75730 PARIS ; France
• Total cost: No data

Participants (1)

Not available

Austria

• EU contribution: No data
• Total cost: No data