Objective
Research objectives and content
The number of transcription factors with known discrete temporal patterns of regional and cell type specific expression in the developing vertebrate nervous system is rapidly increasing. The aim of this research project is to determine the properties and role of a new homeobox gene named X3 that has been cloned from rat brain in the host institution, in the development and maintenance of the mesencephalic dopaminergic system. The following studies will provide critical insights in X3 function during regionalization and cell-fate specification in the nervous system, and will be very useful to understand the molecular mechanisms regulating vertebrate neural development and degeneration or misdevelopment of the mesencephalic dopaminergic system, which relates to neurological and psychiatric diseases like maniac depression, schizophrenia and Parkinson disease. The proposed research plan focuses on several aspects of the X3 gene: It will determine the temporal relationship of expression of X3 and Nurrl (whose loss of expression causes agenesis of the mesDA system in mice). It will determine the transactivating and DNA binding properties of X3 on promoters of genes expressed in the mesDA, as well as its possible functional interaction with Nurrl. Its functional properties will be tested in knockout mice (ongoing project).
Training content (objective, benefit and expected impact)
The development of the present research project will allow the applicant to learn new techniques and acquire fresh knowledge in a field completely different from the previous studies realized during the PhD studies. Specifically, the results obtained from the proposed project on X3, may be exploited for manipulation of dopaminergic cells in vitro, in preparation of grafting, an experimental therapy for Parkinson patients. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3584 CG Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.