Objective
Research objectives and content
The hindbrain is divided into segmental units called rhombomeres which provide compartments for generating regional diversity in the developing CNS. The Hox homeobox genes encode transcription factors that regulate the regional identities of rhombomeres. In Hoxbl mouse mutants rhombomere (r) 4 has an altered identity leading to abnormal migration of facial motor neurons. Associated with these changes is the loss of the signalling molecule Wnt8C in r4. In this proposal I want to determine if Wnt8C is a direct target of Hoxbl. Using reporter genes in transgenic mice I will map the regulatory regions of the Wnt8C gene to identify r4 specific control elements. In vivo and in vitro assays will examine the ability of Hoxbl or other proteins to bind to these sites. Finally to examine whether Wnt8C is involved in the abnormal migration of the cranial motor neurons, I will use explant cultures from Hoxbl mutants to try and rescue the migratory phenotypes with Wnt8C.
Training content (objective, benefit and expected impact)
I am experienced in molecular biology and transcriptional studies in yeast. By selecting Dr Krumlauf's group I will have the opportunity to learn molecular approaches to vertebrate developmental biology with a focus on my major interest in transcriptional regulation at a leading international centre.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NW7 1AA London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.