Objective
Research objectives and content
The aims of this proposal is to study the molecular basis of carbohydrate-carbohydrate interactions recently proposed as mechanism for adhesion and recognition of normal and tumoral cells. Specific types of glycosphingolipids (GSL) and acidic proteoglycans are involved in this process. The research project will incorporate: (a) The synthesis of oligosacharides, epitopes in the cell adhesion process in sponges. (b) Determination of the tridimensional structure by NMR and molecular simulations. (c) Physical-organic studies on relevants interactions. (d) Studies of adhesion by atom force microscopy. This work is a part of a more ambitious programme on the molecular basis of important natural processes of carbohydrate recognition through investigations on synthetic model and natural systems. The work should lead to a better understanding of carbohydrate recognition for influencing biological processes. Training content (objective, benefit and expected impact)
Synthetic skills and understanding of intermolecular interactions are specially important in this area of biological chemistry. A young scientist involved in this programme will have the opportunity to be trained in a multidisciplinar research area.
Links with industry / industrial relevance (22)
Tumor-associated GSL antigens have been used in the development of antitumoral vaccines. New structures of glycosphingolipids and oligosacharides involved in adhesion process are, therefore, targets for cancer therapy and control of cell proliferation. Actually, the host institution has an industrial collaboration in research in a related area of the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
41092 SEVILLA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.